Across TCGA pan-cancer cohorts, HMGB3P30 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMGB3P30’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where HMGB3P30 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB3P30 is over-expressed in tumor.

LUSC, LUAD, and BLCA are the cancer types where HMGB3P30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB3P30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.056	.033	2	view →
LUAD	All	All	+0.042	.001	2	view →
BLCA	All	All	+0.038	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HMGB3P30 RNA expression & survival · all HMGB3P30 data types