Across TCGA pan-cancer cohorts, HMGB3P1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HMGB3P1 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HMGB3P1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HMGB3P1 expression acts as an unfavorable survival marker.

BLCA and READ are the cancer types where HMGB3P1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.059	0.720	<.001	24	view →
READ	DFS	Median	All	0.112	0.845	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: HMGB3P1 tumor-vs-normal RNA expression · all HMGB3P1 data types