HMGB3

Across TCGA patient cohorts, HMGB3 protein abundance is significantly associated with the RNA expression of many other genes, with 19,638 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGB3-associated genes across cancer lineages are MYBL2, CDC20, and HJURP. Each is linked with HMGB3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGB3-to-partner and partner-to-HMGB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB3 versus MYBL2 in GBM, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB3→partner) and Y-score (partner→HMGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYBL2 →	+1.532	+0.626	<.001	<.001	3	9
UCEC	CDC20 →	+1.387	+0.347	.001	.001	3	9
GBM	HJURP →	+1.258	+0.669	<.001	<.001	3	9
GBM	PIMREG →	+1.492	+0.600	<.001	<.001	3	9
LSCC	DKC1 →	+0.729	+0.717	<.001	<.001	3	9
UCEC	KIF2C →	+1.248	+0.350	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,638 associations by consensus.

HMGB3 vs MYBL2 — GBM

Explore this scatter interactively →