HMGB3

Across TCGA patient cohorts, HMGB3 mutation is significantly associated with the RNA expression of many other genes, with 1,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGB3-associated genes across cancer lineages are EIF3JP1, MTND1P6, and SNRPD3. Each is linked with HMGB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB3-to-partner and partner-to-HMGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3JP1 grouped by HMGB3-low versus HMGB3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB3→partner) and Y-score (partner→HMGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EIF3JP1 →	+0.147	+4.163	<.001	.003	3	2
CESC	MTND1P6 →	+0.030	+4.984	<.001	.003	3	2
UCEC	SNRPD3 →	+0.350	+2.485	<.001	<.001	3	1
UCEC	ESS2 →	+0.232	+1.903	.003	<.001	3	1
UCEC	CRYBB2P1 →	+0.440	+2.145	<.001	<.001	3	1
UCEC	HIRA →	+0.320	+2.839	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,790 associations by consensus.

EIF3JP1 by HMGB3 expression — SKCM

Explore this box plot interactively →