HMGB3

Across TCGA cell cohorts, HMGB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,044 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMGB3-associated GO terms across cancer lineages are DNA geometric change, Chromosome condensation, and Regulation of chromosome organization. Each is linked with HMGB3 in more than 18 cancer types. Because this analysis shows association rather than direction, both HMGB3-to-partner and partner-to-HMGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA geometric change grouped by HMGB3-low versus HMGB3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB3→partner) and Y-score (partner→HMGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA geometric change →	+0.138	+1.266	.008	.004	3	19
PANCREAS	Chromosome condensation →	+0.166	+1.923	<.001	<.001	3	17
BLOOD_Leukemia	Regulation of chromosome organization →	+0.085	+1.350	<.001	<.001	3	17
BREAST	Regulation of mitotic cytokinesis →	+0.125	+1.083	<.001	<.001	3	17
BONE	Chromosome segregation →	+0.124	+1.884	.008	<.001	3	17
OESOPHAGUS	Mitotic nuclear division →	+0.114	+0.906	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,044 associations by consensus.

DNA geometric change by HMGB3 expression — OESOPHAGUS

Explore this box plot interactively →