HMGB2

Across TCGA pan-cancer cohorts, HMGB2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HMGB2 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HMGB2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HMGB2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where HMGB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.783	.009	15	view →
CCRCC	DFS	Tertile	III,IV	0.731	0.319	.005	14	view →
HNSC	DFS	Median	All	0.355	0.849	.034	6	view →
OV	DFS	Median	All	0.702	1.000	.035	4	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	4	view →
UCEC	OS	Tertile	III,IV	1.000	0.290	.042	4	view →
LUAD	OS	Median	II,III,IV	0.442	0.899	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HMGB2–LSCC (DFS)

Open the LSCC breakdown →