HMGB2

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HMGB2 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,607 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGB2-associated proteins across cancer lineages are NASP, NCL_S67, and NUF2_S247. Each is linked with HMGB2 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGB2-to-partner and partner-to-HMGB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB2 versus NASP in GBM, with a Pearson correlation of 0.74.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB2→partner) and Y-score (partner→HMGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMNASP →+0.679+0.771<.001<.00139
UCECNCL_S67 →+0.910+1.167<.001<.00139
UCECNUF2_S247 →+1.060+1.608<.001<.00139
OVPCNA →+0.599+0.956<.001.00139
OVPDS5A_T1208 →+0.970+0.794<.001<.00139
HNSCVRK1 →+0.486+1.629<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 19,607 associations by consensus.

HMGB2 vs NASP — GBM

Per-sample scatter of HMGB2 vs NASP in GBM (Pearson r = 0.74).

Explore this scatter interactively →

Exploration