HMGB2

Across TCGA patient cohorts, HMGB2 mutation is significantly associated with the RNA expression of many other genes, with 811 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGB2-associated genes across cancer lineages are RN7SL504P, RPSAP38, and DEF8. Each is linked with HMGB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGB2-to-partner and partner-to-HMGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL504P grouped by HMGB2-low versus HMGB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB2→partner) and Y-score (partner→HMGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL504P →	+0.070	+2.857	.008	.002	3	3
SKCM	RPSAP38 →	+0.061	+4.381	<.001	.006	3	2
UCEC	DEF8 →	+0.359	+2.191	.005	.002	3	2
BLCA	MT-TD →	+0.329	+4.051	<.001	.001	3	2
LUAD	MIR4695 →	+0.348	+7.930	<.001	.008	3	2
UCEC	RN7SL470P →	+0.158	+1.886	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 811 associations by consensus.

RN7SL504P by HMGB2 expression — UCEC

Explore this box plot interactively →