HMGB2

Across TCGA patient cohorts, HMGB2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGB2-associated genes across cancer lineages are eIF4E, ATM, and AMPK_alpha. Each is linked with HMGB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB2-to-partner and partner-to-HMGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HMGB2-low versus HMGB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB2→partner) and Y-score (partner→HMGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.188	+2.321	.023	.034	3	2
UCEC	ATM →	-0.429	-1.584	.016	.036	3	2
BLCA	AMPK_alpha →	+0.295	+2.824	.001	.034	3	1
UCEC	MEK1 →	+0.411	+2.000	.004	.010	3	1
UCEC	MSH2 →	-0.344	-1.990	<.001	.030	3	1
UCEC	Myosin-IIa_pS1943 →	+0.264	+2.013	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by HMGB2 expression — UCEC

Explore this box plot interactively →