HMGB2

Across TCGA cell cohorts, HMGB2 RNA expression is significantly associated with the RNA expression of many other genes, with 10,627 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMGB2-associated genes across cancer lineages are PLK4, CENPU, and C4orf46. Each is linked with HMGB2 in more than 18 cancer types. Because this analysis shows association rather than direction, both HMGB2-to-partner and partner-to-HMGB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB2 versus PLK4 in BONE, with a Pearson correlation of 0.84.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB2→partner) and Y-score (partner→HMGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLK4 →	+1.699	+1.710	<.001	<.001	3	19
OESOPHAGUS	CENPU →	+1.395	+1.053	.001	.003	2	19
OESOPHAGUS	C4orf46 →	+1.261	+1.359	.002	.003	2	18
UPPER_AERODIGESTIVE_TRACT	FBXO5 →	+1.353	+1.117	<.001	<.001	3	17
OESOPHAGUS	CCNA2 →	+1.558	+1.432	<.001	.001	3	17
BONE	KIF15 →	+1.380	+1.637	.006	<.001	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,627 associations by consensus.

HMGB2 vs PLK4 — BONE

Explore this scatter interactively →