HMGB2

Across TCGA cell cohorts, HMGB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,031 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMGB2-associated GO terms across cancer lineages are Spindle elongation, Translesion synthesis, and Nuclear division. Each is linked with HMGB2 in more than 18 cancer types. Because this analysis shows association rather than direction, both HMGB2-to-partner and partner-to-HMGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by HMGB2-low versus HMGB2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB2→partner) and Y-score (partner→HMGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Spindle elongation →	+0.230	+0.828	.006	.007	3	19
OESOPHAGUS	Translesion synthesis →	+0.098	+0.852	<.001	.004	3	19
OESOPHAGUS	Nuclear division →	+0.106	+1.009	.003	<.001	3	19
OESOPHAGUS	Regulation of sister chromatid segregation →	+0.172	+1.216	<.001	<.001	3	18
PANCREAS	Meiotic cell cycle →	+0.059	+0.720	<.001	<.001	3	18
BONE	Attachment of spindle microtubules to kinetochore →	+0.176	+1.270	.002	.004	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,031 associations by consensus.

Spindle elongation by HMGB2 expression — OESOPHAGUS

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