HMGB1P51

Across TCGA pan-cancer cohorts, HMGB1P51 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HMGB1P51 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HMGB1P51 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB1P51 expression acts as an unfavorable survival marker, although some lineages such as OV and ESCA show a favorable association.

UVM, KIRC, and ACC are the cancer types where HMGB1P51 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.343	0.671	<.001	126	view →
KIRC	DFS	Median	All	0.542	0.689	<.001	123	view →
ACC	DFS	Tertile	II,III,IV	0.165	0.569	.013	36	view →
OV	DFS	Quartile	All	0.261	0.151	.004	36	view →
LIHC	DFS	Tertile	All	0.267	0.460	<.001	30	view →
ESCA	OS	Median	III,IV	0.642	0.307	.002	28	view →
READ	OS	Tertile	IV	0.408	0.916	.001	21	view →
PAAD	DFS	Quartile	All	0.179	0.364	.015	14	view →
SKCM	OS	Tertile	IV	0.133	0.621	.019	12	view →
CHOL	OS	Tertile	IV	0.136	0.732	.038	12	view →
TGCT	DFS	Quartile	All	0.271	0.741	<.001	12	view →
THCA	OS	Tertile	IV	0.574	0.916	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HMGB1P51–UVM (DFS)

Open the UVM breakdown →