HMGB1P50

Across TCGA patient cohorts, HMGB1P50 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,558 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P50-associated GO terms across cancer lineages are Telomere maintenance, Regulation of DNA repair, and RNA 3'-end processing. Each is linked with HMGB1P50 in more than 10 cancer types. Because this analysis shows association rather than direction, both HMGB1P50-to-partner and partner-to-HMGB1P50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere maintenance grouped by HMGB1P50-low versus HMGB1P50-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P50→partner) and Y-score (partner→HMGB1P50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Telomere maintenance →	+0.062	+0.145	<.001	<.001	3	11
STAD	Regulation of DNA repair →	+0.061	+0.138	<.001	<.001	3	10
STAD	RNA 3'-end processing →	+0.067	+0.173	<.001	<.001	3	10
STAD	Regulation of protein binding →	+0.059	+0.134	<.001	<.001	3	10
ESCA	DNA biosynthetic process →	+0.065	+0.166	<.001	<.001	3	9
STAD	Protein modification by small protein removal →	+0.062	+0.132	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,558 associations by consensus.

Telomere maintenance by HMGB1P50 expression — STAD

Explore this box plot interactively →