HMGB1P49

Across TCGA patient cohorts, HMGB1P49 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,766 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P49-associated GO terms across cancer lineages are Spliceosomal complex assembly, Positive regulation of proteasomal protein catabolic process, and Regulation of organelle assembly. Each is linked with HMGB1P49 in more than 17 cancer types. Because this analysis shows association rather than direction, both HMGB1P49-to-partner and partner-to-HMGB1P49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal complex assembly grouped by HMGB1P49-low versus HMGB1P49-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P49→partner) and Y-score (partner→HMGB1P49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Spliceosomal complex assembly →	+0.066	+0.401	<.001	<.001	3	18
ESCA	Positive regulation of proteasomal protein catabolic process →	+0.061	+0.258	.004	.005	2	18
ESCA	Regulation of organelle assembly →	+0.059	+0.307	.003	.001	2	18
STAD	Phosphatidylinositol metabolic process →	+0.040	+0.270	<.001	<.001	3	16
STAD	Regulation of canonical Wnt signaling pathway →	+0.051	+0.256	<.001	<.001	3	16
ESCA	Regulation of proteasomal protein catabolic process →	+0.062	+0.277	.005	.002	1	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,766 associations by consensus.

Spliceosomal complex assembly by HMGB1P49 expression — STAD

Explore this box plot interactively →