HMGB1P48

Across TCGA patient cohorts, HMGB1P48 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,488 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P48-associated GO terms across cancer lineages are Regulation of double-strand break repair, Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, and RNA 3'-end processing. Each is linked with HMGB1P48 in more than 11 cancer types. Because this analysis shows association rather than direction, both HMGB1P48-to-partner and partner-to-HMGB1P48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by HMGB1P48-low versus HMGB1P48-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P48→partner) and Y-score (partner→HMGB1P48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of double-strand break repair →	+0.069	+0.344	<.001	<.001	3	12
ESCA	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.076	+0.301	<.001	<.001	3	12
ESCA	RNA 3'-end processing →	+0.082	+0.362	<.001	<.001	3	12
ESCA	Nucleus organization →	+0.068	+0.371	<.001	<.001	3	12
ESCA	Nucleotide-excision repair →	+0.056	+0.337	<.001	<.001	3	12
STAD	Spindle localization →	+0.058	+0.322	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,488 associations by consensus.

Regulation of double-strand break repair by HMGB1P48 expression — ESCA

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