HMGB1P42

Across TCGA patient cohorts, HMGB1P42 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,000 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P42-associated GO terms across cancer lineages are Somatic diversification of immunoglobulins, Signal transduction by p53 class mediator, and Peptidyl-lysine modification. Each is linked with HMGB1P42 in more than 9 cancer types. Because this analysis shows association rather than direction, both HMGB1P42-to-partner and partner-to-HMGB1P42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Somatic diversification of immunoglobulins grouped by HMGB1P42-low versus HMGB1P42-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P42→partner) and Y-score (partner→HMGB1P42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Somatic diversification of immunoglobulins →	+0.074	+0.079	<.001	<.001	3	10
STAD	Signal transduction by p53 class mediator →	+0.077	+0.075	<.001	<.001	3	10
STAD	Peptidyl-lysine modification →	+0.070	+0.080	<.001	<.001	3	9
STAD	U2-type prespliceosome assembly →	+0.092	+0.067	<.001	<.001	3	9
STAD	Monosaccharide biosynthetic process →	+0.063	+0.076	<.001	<.001	3	9
STAD	Regulation of DNA recombination →	+0.072	+0.092	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,000 associations by consensus.

Somatic diversification of immunoglobulins by HMGB1P42 expression — STAD

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