HMGB1P41

Across TCGA pan-cancer cohorts, HMGB1P41 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HMGB1P41’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where HMGB1P41 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P41 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

CHOL, THCA, and PRAD are the cancer types where HMGB1P41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	All	+0.564	.003	3	view →
THCA	Female	II,III,IV	−0.275	.004	3	view →
PRAD	All	All	+0.295	.007	2	view →
KICH	All	All	−0.233	.007	2	view →
KIRP	All	All	−0.189	.004	2	view →
HNSC	Male	IV	+0.176	.027	2	view →
LIHC	All	All	+0.074	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HMGB1P41–CHOL

Open the CHOL breakdown →