HMGB1P40

Across TCGA patient cohorts, HMGB1P40 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,462 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P40-associated GO terms across cancer lineages are Regulation of chromosome organization, DNA-templated transcription initiation, and Nuclear pore organization. Each is linked with HMGB1P40 in more than 25 cancer types. Because this analysis shows association rather than direction, both HMGB1P40-to-partner and partner-to-HMGB1P40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome organization grouped by HMGB1P40-low versus HMGB1P40-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P40→partner) and Y-score (partner→HMGB1P40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Regulation of chromosome organization →	+0.072	+0.350	<.001	<.001	3	26
STAD	DNA-templated transcription initiation →	+0.050	+0.217	<.001	<.001	3	25
STAD	Nuclear pore organization →	+0.066	+0.300	<.001	<.001	3	25
STAD	Mitotic spindle organization →	+0.067	+0.265	<.001	<.001	3	25
STAD	Telomere maintenance →	+0.055	+0.245	<.001	<.001	3	25
THYM	Cell cycle G2/M phase transition →	+0.055	+0.270	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,462 associations by consensus.

Regulation of chromosome organization by HMGB1P40 expression — THYM

Explore this box plot interactively →