HMGB1P36

Across TCGA pan-cancer cohorts, HMGB1P36 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMGB1P36’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where HMGB1P36 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P36 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BRCA, BLCA, and KIRC are the cancer types where HMGB1P36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.027	.007	4	view →
BLCA	All	III,IV	−0.046	.044	3	view →
KIRC	Male	II,III,IV	−0.014	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HMGB1P36–BRCA

Open the BRCA breakdown →