HMGB1P31

Across TCGA patient cohorts, HMGB1P31 RNA expression is significantly associated with the RNA expression of many other genes, with 18,357 significant associations in total. UVM shows the largest number of these associations.

The most reproducible HMGB1P31-associated genes across cancer lineages are AGO3, PPP1R12A, and SF3B1. Each is linked with HMGB1P31 in more than 31 cancer types. Because this analysis shows association rather than direction, both HMGB1P31-to-partner and partner-to-HMGB1P31 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB1P31 versus AGO3 in UVM, with a Pearson correlation of 0.72.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P31→partner) and Y-score (partner→HMGB1P31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	AGO3 →	+0.702	+0.810	<.001	<.001	3	32
UVM	PPP1R12A →	+1.302	+0.807	<.001	<.001	3	32
UVM	SF3B1 →	+1.446	+0.819	<.001	<.001	3	31
UVM	SOS1 →	+1.396	+0.804	<.001	<.001	3	31
UVM	RLF →	+1.154	+0.771	<.001	<.001	3	31
UVM	CREB1 →	+1.189	+0.756	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,357 associations by consensus.

HMGB1P31 vs AGO3 — UVM

Explore this scatter interactively →