HMGB1P30

Across TCGA pan-cancer cohorts, HMGB1P30 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HMGB1P30 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HMGB1P30 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB1P30 expression acts as an unfavorable survival marker, although some lineages such as ACC show a favorable association.

HNSC, BRCA, and UCEC are the cancer types where HMGB1P30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.246	0.679	<.001	54	view →
BRCA	DFS	Tertile	II,III,IV	0.495	0.525	.031	42	view →
UCEC	OS	Tertile	III,IV	0.117	0.615	.001	36	view →
SARC	OS	Tertile	All	0.169	0.530	<.001	36	view →
KIRP	OS	Tertile	III,IV	0.236	0.809	<.001	36	view →
SKCM	DFS	Tertile	IV	0.038	0.477	<.001	33	view →
LUAD	OS	Tertile	III,IV	0.223	0.677	.006	27	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	27	view →
ACC	OS	Median	IV	0.760	0.346	.005	12	view →
GBM	OS	Tertile	All	0.281	0.426	.045	9	view →
LGG	OS	Tertile	All	0.182	0.465	.023	9	view →
STAD	DFS	Tertile	IV	0.144	0.455	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HMGB1P30–HNSC (DFS)

Open the HNSC breakdown →