HMGB1P28

Across TCGA pan-cancer cohorts, HMGB1P28 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HMGB1P28’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HMGB1P28 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGB1P28 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA and BRCA are the cancer types where HMGB1P28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.120	.010	4	view →
BRCA	All	III,IV	+0.020	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

HMGB1P28–THCA

Open the THCA breakdown →