HMGB1P27

Across TCGA patient cohorts, HMGB1P27 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,954 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P27-associated GO terms across cancer lineages are Cellular senescence, Regulation of cell-substrate junction organization, and Positive regulation of proteasomal protein catabolic process. Each is linked with HMGB1P27 in more than 25 cancer types. Because this analysis shows association rather than direction, both HMGB1P27-to-partner and partner-to-HMGB1P27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular senescence grouped by HMGB1P27-low versus HMGB1P27-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P27→partner) and Y-score (partner→HMGB1P27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Cellular senescence →	+0.052	+0.172	<.001	<.001	3	26
TGCT	Regulation of cell-substrate junction organization →	+0.063	+0.177	<.001	<.001	3	24
STAD	Positive regulation of proteasomal protein catabolic process →	+0.036	+0.083	<.001	<.001	3	23
ESCA	Regulation of cellular response to transforming growth factor beta stimulus →	+0.038	+0.190	.001	.001	2	24
DLBC	Vacuole organization →	+0.052	+0.150	<.001	<.001	3	23
DLBC	Response to UV →	+0.043	+0.164	.003	.003	2	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,954 associations by consensus.

Cellular senescence by HMGB1P27 expression — ESCA

Explore this box plot interactively →