Across TCGA pan-cancer cohorts, HMGB1P26 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HMGB1P26’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGB1P26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P26 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where HMGB1P26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.095	<.001	9	view →
LIHC	All	All	+0.027	.003	7	view →
COAD	All	II,III,IV	+0.146	.033	3	view →
THCA	All	III,IV	+0.058	.016	2	view →
LUSC	Female	III,IV	−0.155	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HMGB1P26 RNA expression & survival · all HMGB1P26 data types