HMGB1P23

Across TCGA pan-cancer cohorts, HMGB1P23 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HMGB1P23’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HMGB1P23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P23 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

KICH, STAD, and BRCA are the cancer types where HMGB1P23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	+0.836	<.001	6	view →
STAD	All	All	+0.215	.030	4	view →
BRCA	All	IV	−0.190	.002	2	view →
KIRC	Female	All	−0.079	.034	2	view →
THCA	Female	II,III,IV	+0.050	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HMGB1P23–KICH

Open the KICH breakdown →