Across TCGA pan-cancer cohorts, HMGB1P13 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated HMGB1P13 data layer.
The strongest signal is observed in uveal melanoma (UVM), where higher HMGB1P13 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMGB1P13 expression acts as an unfavorable survival marker, although some lineages such as LGG show a favorable association.
UVM, LUSC, and MESO are the cancer types where HMGB1P13 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.