HMGB1P1

Across TCGA patient cohorts, HMGB1P1 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HMGB1P1-associated genes across cancer lineages are RNA5SP414, RNU6-591P, and RNA5SP415. Each is linked with HMGB1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB1P1-to-partner and partner-to-HMGB1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by HMGB1P1-low versus HMGB1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P1→partner) and Y-score (partner→HMGB1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+1.633	+4.255	<.001	<.001	3	2
BRCA	RNU6-591P →	+0.263	+8.471	<.001	.005	3	2
UCEC	RNA5SP415 →	+1.556	+3.488	<.001	.008	3	2
COAD	RNU4-79P →	+0.541	+7.734	<.001	<.001	3	2
COAD	RNU6-1305P →	+1.510	+6.122	<.001	.002	3	2
COAD	RNU6-905P →	+0.470	+6.251	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

RNA5SP414 by HMGB1P1 expression — UCEC

Explore this box plot interactively →