HMGA2

Across TCGA patient cohorts, HMGA2 mutation is significantly associated with the RNA expression of many other genes, with 4,700 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGA2-associated genes across cancer lineages are RNU6-726P, ARL14EP, and ZCCHC10. Each is linked with HMGA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGA2-to-partner and partner-to-HMGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-726P grouped by HMGA2-low versus HMGA2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA2→partner) and Y-score (partner→HMGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-726P →	+0.457	+5.788	<.001	.003	3	2
UCEC	ARL14EP →	+0.371	+2.928	.002	<.001	3	2
UCEC	ZCCHC10 →	+0.392	+1.748	.001	.002	3	2
UCEC	MIER3 →	+0.461	+2.010	.002	<.001	3	2
UCEC	RAPGEF6 →	+0.298	+2.016	.002	.001	3	2
UCEC	PACRGL →	+0.424	+2.321	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,700 associations by consensus.

RNU6-726P by HMGA2 expression — BLCA

Explore this box plot interactively →