HMGA2

Across TCGA patient cohorts, HMGA2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGA2-associated genes across cancer lineages are 4E-BP1_pT37_T46, eEF2, and A-Raf_pS299. Each is linked with HMGA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGA2-to-partner and partner-to-HMGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by HMGA2-low versus HMGA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA2→partner) and Y-score (partner→HMGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.405	-2.687	.002	.005	3	2
UCEC	eEF2 →	+0.417	+1.662	<.001	.011	3	1
UCEC	A-Raf_pS299 →	-0.131	-2.415	.001	.003	3	1
UCEC	ERK2 →	+0.186	+1.662	.006	.011	3	1
UCEC	FASN →	+0.296	+2.222	.033	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.405	.025	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1_pT37_T46 by HMGA2 expression — UCEC

Explore this box plot interactively →