HMGA2

Across TCGA cell cohorts, HMGA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,676 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HMGA2-associated GO terms across cancer lineages are Oncogene-induced cell senescence, Chondrocyte proliferation, and Positive regulation of stem cell proliferation. Each is linked with HMGA2 in more than 15 cancer types. Because this analysis shows association rather than direction, both HMGA2-to-partner and partner-to-HMGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oncogene-induced cell senescence grouped by HMGA2-low versus HMGA2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA2→partner) and Y-score (partner→HMGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Oncogene-induced cell senescence →	+0.238	+3.694	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Chondrocyte proliferation →	+1.191	+3.657	.001	<.001	3	13
STOMACH	Positive regulation of stem cell proliferation →	+0.200	+3.010	<.001	<.001	3	11
BONE	Negative regulation of double-strand break repair via nonhomologous end joining →	+0.124	+2.470	<.001	<.001	3	11
BONE	Regulation of cell proliferation in bone marrow →	+0.222	+3.866	<.001	<.001	2	12
SOFT_TISSUE	Positive regulation of cell proliferation in bone marrow →	+0.299	+1.683	<.001	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,676 associations by consensus.

Oncogene-induced cell senescence by HMGA2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →