HMGA1P8

Across TCGA pan-cancer cohorts, HMGA1P8 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HMGA1P8 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HMGA1P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGA1P8 expression acts as an unfavorable survival marker, although some lineages such as OV and UVM show a favorable association.

LIHC, LGG, and HNSC are the cancer types where HMGA1P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.362	0.494	.004	41	view →
LGG	DFS	Tertile	All	0.372	0.522	.001	36	view →
HNSC	OS	Median	All	0.255	0.536	<.001	35	view →
KIRC	DFS	Quartile	II,III,IV	0.392	0.635	.006	32	view →
CHOL	DFS	Tertile	II,III,IV	0.085	0.607	.006	29	view →
OV	OS	Tertile	IV	0.552	0.297	.008	24	view →
LUSC	DFS	Median	III,IV	0.417	0.662	.006	19	view →
UVM	DFS	Median	All	0.684	0.455	.013	12	view →
THCA	DFS	Quartile	IV	0.712	1.000	.014	9	view →
ACC	DFS	Tertile	IV	0.656	0.150	.024	9	view →
LAML	DFS	Tertile	All	0.297	0.477	.042	8	view →
DLBC	DFS	Tertile	All	0.569	0.889	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

HMGA1P8–LIHC (DFS)

Open the LIHC breakdown →