HMCN2

Across TCGA patient cohorts, HMCN2 mutation is significantly associated with the RNA expression of many other genes, with 4,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMCN2-associated genes across cancer lineages are RN7SL314P, LINC01072, and RNU6-716P. Each is linked with HMCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMCN2-to-partner and partner-to-HMCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL314P grouped by HMCN2-low versus HMCN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCN2→partner) and Y-score (partner→HMCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL314P →	+0.101	+4.984	.008	.003	3	2
UCEC	LINC01072 →	+0.097	+1.994	<.001	<.001	3	2
CESC	RNU6-716P →	+0.269	+4.757	<.001	.004	3	1
CESC	MT-TW →	+0.825	+4.037	<.001	.005	3	1
CESC	RNU6-821P →	+0.277	+4.559	<.001	.006	3	1
CESC	LINC01020 →	+0.018	+4.384	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,072 associations by consensus.

RN7SL314P by HMCN2 expression — CESC

Explore this box plot interactively →