HMCN2

Across TCGA cell cohorts, HMCN2 mutation is significantly associated with the RNA expression of many other genes, with 600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMCN2-associated genes across cancer lineages are TRPV5, KRT26, and C9orf57. Each is linked with HMCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMCN2-to-partner and partner-to-HMCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPV5 grouped by HMCN2-low versus HMCN2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCN2→partner) and Y-score (partner→HMCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRPV5 →	+0.101	+4.459	<.001	.001	3	1
SOFT_TISSUE	KRT26 →	+0.015	+4.515	<.001	<.001	3	1
SOFT_TISSUE	C9orf57 →	+0.055	+4.169	<.001	.002	3	1
SOFT_TISSUE	HBM →	+0.068	+4.169	<.001	.002	3	1
SOFT_TISSUE	KRTAP4-11 →	+0.099	+4.142	<.001	.003	3	1
SOFT_TISSUE	KRTAP10-10 →	+0.014	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

TRPV5 by HMCN2 expression — SOFT_TISSUE

Explore this box plot interactively →