HMCN1

Across TCGA patient cohorts, HMCN1 mutation is significantly associated with the RNA expression of many other genes, with 9,333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMCN1-associated genes across cancer lineages are BEX2, CDT1, and UBE2T. Each is linked with HMCN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HMCN1-to-partner and partner-to-HMCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BEX2 grouped by HMCN1-low versus HMCN1-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCN1→partner) and Y-score (partner→HMCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	BEX2 →	-1.521	-2.186	.002	.008	3	6
UCEC	CDT1 →	+0.637	+1.664	<.001	<.001	3	6
LUAD	UBE2T →	+0.599	+2.110	.001	.002	3	6
COAD	FAM72B →	+0.340	+1.428	<.001	.001	3	6
LUAD	RNFT2 →	+0.426	+1.900	.006	.001	3	6
LUAD	PLAGL1 →	-0.608	-1.988	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,333 associations by consensus.

BEX2 by HMCN1 expression — ESCA

Explore this box plot interactively →