HMCN1

Across TCGA patient cohorts, HMCN1 mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMCN1-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with HMCN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HMCN1-to-partner and partner-to-HMCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HMCN1-low versus HMCN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCN1→partner) and Y-score (partner→HMCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.435	+2.087	<.001	.004	3	7
COAD	Caspase-7-cleavedD198 →	+0.947	+1.815	<.001	<.001	3	7
UCEC	Cyclin-B1 →	+0.341	+0.868	.008	.014	3	6
BRCA	c-Kit →	-0.447	-2.222	.008	.011	3	5
COAD	Rictor →	-0.579	-1.584	.032	.014	3	5
BLCA	Caveolin-1 →	-0.400	-1.362	.006	.028	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

ASNS by HMCN1 expression — COAD

Explore this box plot interactively →