HMCN1

Across TCGA cell cohorts, HMCN1 mutation is significantly associated with the RNA expression of many other genes, with 3,273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMCN1-associated genes across cancer lineages are TUFM, JOSD1, and RBFOX2. Each is linked with HMCN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMCN1-to-partner and partner-to-HMCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUFM grouped by HMCN1-low versus HMCN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCN1→partner) and Y-score (partner→HMCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TUFM →	+0.263	+1.364	.003	.002	3	5
LARGE_INTESTINE	JOSD1 →	+0.552	+2.906	<.001	<.001	3	4
LARGE_INTESTINE	RBFOX2 →	+0.640	+1.364	.001	.002	3	4
LARGE_INTESTINE	TRIM35 →	+0.568	+2.115	<.001	.001	3	4
LARGE_INTESTINE	VPS53 →	+0.620	+2.459	.001	.003	3	4
LARGE_INTESTINE	RNF166 →	+0.532	+1.678	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,273 associations by consensus.

TUFM by HMCN1 expression — LARGE_INTESTINE

Explore this box plot interactively →