Across TCGA patient cohorts, HMCES mutation is significantly associated with the RNA expression of many other genes, with 2,262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMCES-associated genes across cancer lineages are SNRPGP8, RNA5SP374, and SNORA25B. Each is linked with HMCES in more than 2 cancer types. Because this analysis shows association rather than direction, both HMCES-to-partner and partner-to-HMCES results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCES→partner) and Y-score (partner→HMCES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP8 →	+0.105	+2.937	.005	.009	3	3
BRCA	RNA5SP374 →	+0.217	+8.055	<.001	.007	3	2
BRCA	SNORA25B →	+0.210	+7.731	.004	.009	3	2
BRCA	RNU7-82P →	+0.415	+7.731	<.001	.009	3	2
BLCA	MTND6P20 →	+0.059	+7.640	<.001	.009	3	2
BLCA	RN7SL719P →	+0.099	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,262 associations by consensus.

Exploration

HMCES survival (RNA) · tumor vs normal (RNA) · all HMCES data types