Across TCGA patient cohorts, HMCES mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMCES-associated genes across cancer lineages are CD8+ naive T-cells, Epithelial cells, and Erythrocytes. Each is linked with HMCES in more than 1 cancer types. Because this analysis shows association rather than direction, both HMCES-to-partner and partner-to-HMCES results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCES→partner) and Y-score (partner→HMCES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ naive T-cells →	+0.024	+3.016	.045	.019	3	1
UCEC	Epithelial cells →	-0.103	-3.159	.001	.019	3	1
UCEC	Erythrocytes →	+0.030	+2.241	.006	.031	3	1
UCEC	Macrophages M2 →	+0.010	+2.921	.026	.030	3	1
UCEC	MEP →	+0.036	+2.491	.003	.010	3	1
UCEC	Mesangial cells →	-0.050	-3.305	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

HMCES survival (RNA) · tumor vs normal (RNA) · all HMCES data types