Across TCGA cell cohorts, HMCES RNA expression is significantly associated with the go_rna of many other GO terms, with 4,321 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMCES-associated GO terms across cancer lineages are Spindle elongation, Double-strand break repair via break-induced replication, and Cell cycle DNA replication initiation. Each is linked with HMCES in more than 12 cancer types. Because this analysis shows association rather than direction, both HMCES-to-partner and partner-to-HMCES results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCES→partner) and Y-score (partner→HMCES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Spindle elongation →	+0.249	+0.737	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.222	+1.086	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cell cycle DNA replication initiation →	+0.200	+0.951	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Nuclear cell cycle DNA replication initiation →	+0.200	+0.951	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication initiation →	+0.200	+0.951	<.001	<.001	3	12
OESOPHAGUS	DNA replication →	+0.098	+0.435	.006	.007	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,321 associations by consensus.

Exploration

HMCES survival (RNA) · tumor vs normal (RNA) · all HMCES data types