HLX

Across TCGA patient cohorts, HLX protein abundance is significantly associated with the RNA expression of many other genes, with 3,703 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLX-associated genes across cancer lineages are HIF1A, DOK5, and CTSZ. Each is linked with HLX in more than 1 cancer types. Because this analysis shows association rather than direction, both HLX-to-partner and partner-to-HLX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLX versus HIF1A in LSCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLX→partner) and Y-score (partner→HLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HIF1A →	+0.508	+0.308	.001	.005	3	1
LSCC	DOK5 →	+0.429	+0.347	<.001	.002	3	1
LSCC	CTSZ →	+0.402	+0.348	.005	.003	3	1
LSCC	MYL9 →	+0.830	+0.304	.002	.009	3	1
LSCC	AHCY →	-0.673	-0.459	<.001	<.001	3	1
LSCC	PIGU →	-0.334	-0.278	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,703 associations by consensus.

HLX vs HIF1A — LSCC

Explore this scatter interactively →