HLX

Across TCGA patient cohorts, HLX mutation is significantly associated with the RNA expression of many other genes, with 1,023 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLX-associated genes across cancer lineages are MIR3679, MIR549A, and CMIP. Each is linked with HLX in more than 2 cancer types. Because this analysis shows association rather than direction, both HLX-to-partner and partner-to-HLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3679 grouped by HLX-low versus HLX-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLX→partner) and Y-score (partner→HLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR3679 →	+0.405	+3.691	<.001	.004	3	3
CESC	MIR549A →	+0.453	+6.342	<.001	.001	3	2
UCEC	CMIP →	+0.418	+2.732	.006	.003	3	2
UCEC	WHAMM →	+0.521	+3.732	<.001	<.001	3	2
UCEC	ATPAF2 →	+0.350	+2.258	.002	.001	3	2
UCEC	SLC25A30 →	+0.511	+2.447	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,023 associations by consensus.

MIR3679 by HLX expression — BLCA

Explore this box plot interactively →