HLX

Across TCGA patient cohorts, HLX mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLX-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and eEF2K. Each is linked with HLX in more than 2 cancer types. Because this analysis shows association rather than direction, both HLX-to-partner and partner-to-HLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HLX-low versus HLX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLX→partner) and Y-score (partner→HLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.738	+2.019	.001	.017	3	3
LUSC	eEF2 →	+0.235	+3.009	.013	.019	3	2
LUAD	eEF2K →	+0.314	+3.000	.022	.035	3	2
UCEC	Bax →	+0.244	+1.906	.011	.016	3	2
UCEC	Cyclin-E1 →	+0.349	+2.999	.046	.035	3	2
LUSC	4E-BP1_pT70 →	+0.241	+2.821	.029	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by HLX expression — UCEC

Explore this box plot interactively →