Across TCGA pan-cancer cohorts, HLFP1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated HLFP1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HLFP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HLFP1 expression acts as an unfavorable survival marker.

BLCA, LUAD, and COAD are the cancer types where HLFP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.069	0.710	<.001	108	view →
LUAD	OS	Tertile	All	0.245	0.679	<.001	72	view →
COAD	OS	Tertile	III,IV	0.376	0.792	<.001	63	view →
ESCA	OS	Tertile	All	0.401	0.948	<.001	54	view →
CHOL	DFS	Tertile	III,IV	0.031	0.505	.003	45	view →
BRCA	DFS	Tertile	All	0.664	0.905	<.001	36	view →
LAML	DFS	Median	All	0.429	0.646	.001	30	view →
TGCT	DFS	Tertile	All	0.089	0.681	.003	18	view →
LIHC	DFS	Tertile	All	0.209	0.324	.027	18	view →
UCEC	OS	Tertile	All	0.738	0.879	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

Exploration

Same gene, other analysis: HLFP1 tumor-vs-normal RNA expression · all HLFP1 data types