HLF

Across TCGA patient cohorts, HLF RNA expression is significantly associated with the protein abundance of many other proteins, with 25,671 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HLF-associated proteins across cancer lineages are KANK2, PLOD2, and PSMD2. Each is linked with HLF in more than 7 cancer types. Because this analysis shows association rather than direction, both HLF-to-partner and partner-to-HLF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLF versus KANK2 in UCEC, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLF→partner) and Y-score (partner→HLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KANK2 →	+0.612	+0.842	<.001	<.001	3	8
CCRCC	PLOD2 →	-0.805	-0.794	<.001	<.001	3	7
BRCA	PSMD2 →	-0.151	-1.013	<.001	<.001	3	7
OV	PSME4 →	-0.340	-0.788	<.001	<.001	3	7
GBM	IKBIP →	-0.446	-0.884	<.001	<.001	3	7
OV	ADH5 →	+0.488	+0.828	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,671 associations by consensus.

HLF vs KANK2 — UCEC

Explore this scatter interactively →