HLF

Across TCGA patient cohorts, HLF mutation is significantly associated with the RNA expression of many other genes, with 3,371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLF-associated genes across cancer lineages are MIR128-1, RN7SL478P, and RPS6P20. Each is linked with HLF in more than 1 cancer types. Because this analysis shows association rather than direction, both HLF-to-partner and partner-to-HLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR128-1 grouped by HLF-low versus HLF-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLF→partner) and Y-score (partner→HLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR128-1 →	+0.302	+3.542	<.001	.007	3	2
UCEC	RN7SL478P →	+0.164	+1.565	.001	.004	3	2
UCEC	RPS6P20 →	+0.061	+1.621	.002	.001	3	2
UCEC	RPL31P47 →	+0.275	+1.925	<.001	.002	3	2
COAD	LINC01995 →	+0.158	+4.418	<.001	.008	3	2
UCEC	LINC02438 →	+0.714	+3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,371 associations by consensus.

MIR128-1 by HLF expression — CESC

Explore this box plot interactively →