HLF

Across TCGA cell cohorts, HLF RNA expression is significantly associated with the go_rna of many other GO terms, with 2,290 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLF-associated GO terms across cancer lineages are Cell-matrix adhesion, Translational initiation, and Regulation of interleukin-8 production. Each is linked with HLF in more than 6 cancer types. Because this analysis shows association rather than direction, both HLF-to-partner and partner-to-HLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-matrix adhesion grouped by HLF-low versus HLF-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLF→partner) and Y-score (partner→HLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cell-matrix adhesion →	-0.104	-0.873	<.001	.002	3	7
SOFT_TISSUE	Translational initiation →	+0.067	+0.540	<.001	.008	3	6
PANCREAS	Regulation of interleukin-8 production →	-0.059	-0.251	.001	.002	3	6
SOFT_TISSUE	Positive regulation of CD8-positive, alpha-beta T cell activation →	-0.222	-0.673	<.001	.001	3	5
LIVER	Regulation of fever generation →	-1.643	-1.976	<.001	.001	3	5
BREAST	Regulation of glutamate uptake involved in transmission of nerve impulse →	-0.190	-0.797	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,290 associations by consensus.

Cell-matrix adhesion by HLF expression — BREAST

Explore this box plot interactively →