Across TCGA patient cohorts, HLA-U RNA expression is significantly associated with the go_rna of many other GO terms, with 7,022 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible HLA-U-associated GO terms across cancer lineages are MDA-5 signaling pathway, Positive regulation of regulatory T cell differentiation, and Antigen processing and presentation of endogenous antigen. Each is linked with HLA-U in more than 23 cancer types. Because this analysis shows association rather than direction, both HLA-U-to-partner and partner-to-HLA-U results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-U→partner) and Y-score (partner→HLA-U) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	MDA-5 signaling pathway →	+0.132	+1.128	<.001	.005	1	24
UVM	Positive regulation of regulatory T cell differentiation →	+0.048	+1.191	.001	.002	2	23
UVM	Antigen processing and presentation of endogenous antigen →	+0.053	+1.529	.001	<.001	3	21
UVM	Antigen processing and presentation of endogenous peptide antigen →	+0.066	+1.605	<.001	<.001	3	21
ESCA	Positive regulation of tolerance induction →	+0.077	+1.032	<.001	<.001	3	21
UCS	Regulation of T cell mediated immunity →	+0.040	+1.445	<.001	.004	2	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,022 associations by consensus.

Exploration

HLA-U survival (RNA) · tumor vs normal (RNA) · all HLA-U data types