HLA-T

Across TCGA pan-cancer cohorts, HLA-T RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HLA-T data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HLA-T RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-T expression acts as an unfavorable survival marker, although some lineages such as BLCA and READ show a favorable association.

BLCA, HNSC, and READ are the cancer types where HLA-T RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.783	0.654	.004	44	view →
HNSC	OS	Quartile	All	0.534	0.800	.001	29	view →
READ	DFS	Median	All	0.904	0.677	.005	26	view →
STAD	DFS	Quartile	II,III,IV	0.307	0.484	.015	25	view →
COAD	OS	Tertile	IV	0.470	0.899	.007	23	view →
LUSC	DFS	Median	III,IV	0.511	0.772	.001	17	view →
LUAD	DFS	Median	All	0.476	0.243	.006	14	view →
UCEC	DFS	Median	II,III,IV	0.689	0.398	.024	14	view →
SKCM	OS	Quartile	II,III,IV	0.379	0.220	.015	13	view →
ESCA	OS	Median	All	0.603	0.765	.019	12	view →
ACC	DFS	Quartile	IV	0.641	0.221	.017	12	view →
KIRC	OS	Quartile	All	0.920	0.834	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HLA-T–BLCA (OS)

Open the BLCA breakdown →