HLA-K

Across TCGA pan-cancer cohorts, HLA-K Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HLA-K data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HLA-K Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HLA-K expression acts as an unfavorable survival marker.

HNSC, UCEC, and COAD are the cancer types where HLA-K Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.143	0.687	<.001	18	view →
UCEC	OS	Median	III,IV	0.061	0.588	.018	12	view →
COAD	DFS	Median	All	0.160	0.689	.017	12	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HLA-K–HNSC (OS)

Open the HNSC breakdown →