Across TCGA patient cohorts, HLA-H RNA expression is significantly associated with the go_rna of many other GO terms, with 7,144 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible HLA-H-associated GO terms across cancer lineages are Tolerance induction dependent upon immune response, Immune response-inhibiting cell surface receptor signaling pathway, and Type II interferon-mediated signaling pathway. Each is linked with HLA-H in more than 30 cancer types. Because this analysis shows association rather than direction, both HLA-H-to-partner and partner-to-HLA-H results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-H→partner) and Y-score (partner→HLA-H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	Tolerance induction dependent upon immune response →	+0.130	+1.078	<.001	<.001	3	31
DLBC	Immune response-inhibiting cell surface receptor signaling pathway →	+0.136	+1.251	<.001	<.001	3	31
TGCT	Type II interferon-mediated signaling pathway →	+0.074	+0.908	<.001	<.001	3	30
CHOL	Antigen processing and presentation of peptide antigen →	+0.067	+1.426	.004	.003	2	31
CHOL	Antigen processing and presentation of endogenous peptide antigen →	+0.089	+1.685	.001	.001	2	31
LAML	Fc receptor mediated inhibitory signaling pathway →	+0.155	+0.738	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,144 associations by consensus.

Exploration

HLA-H survival (RNA) · tumor vs normal (RNA) · all HLA-H data types